Beilstein J. Org. Chem.2021,17, 2295–2301, doi:10.3762/bjoc.17.147
scaffold.
Keywords: deazapurines; heterocycles; pyrrolopyrimidines; queuosine; RNA cofactors; RNAmethylation; Introduction
Methylated preQ1 has attracted much attention recently because this compound has been found to function as cofactor for the conserved fold of a non-coding RNA, namely the preQ1
(preQ1) [1]. Thus far, present-day riboswitches have only been known to bind – but not to be able to react – with their ligands [2][3]. This new finding now opens exciting avenues for the development of RNA labeling tools [4], in particular, for RNAmethylation, and more generally, for RNA alkylation. To
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Graphical Abstract
Scheme 1:
Chemical structures of queuine (Q base) and the hypermodified nucleoside queuosine (Q), the natural...